产品基本信息

• 产品货号 BD-PB5135
• 别名 Protein phosphatase 1 regulatory subunit 12A, Myosin phosphatase-targeting subunit 1, Myosin phosphatase target subunit 1, Protein phosphatase myosin-binding subunit, PPP1R12A, MBS, MYPT1
• 产品名称 MYPT1 (Phospho Ser668) Rabbit Polyclonal Antibody
• 类别 抗原抗体
• Clonality Polyclonal
• 推荐应用 WB
• 反应种属 Human
• 存储缓冲液 Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
• 特异性 This Phospho-MYPT1 (Ser668) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 641-674 amino acids from human MYPT1.
• 稀释度 WB 1:1000
• 预测分子量 115kDa
• 运输及保存条件 Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• 宿主 Rabbit
• 同种型 IgG
• 背景介绍 Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity.
• 组织表达 Expressed in striated muscles, specifically in type 2a fibers (at protein level).
• 细胞定位 Cytoplasm. Cytoplasm, cytoskeleton, stress fiber. Note=Also along actomyosin filaments
• 功能 Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.

图片

Western blot analysis of lysates from Hela, Jurkat cell line, untreated or treated with Calyculin A, 100nM, using or Tubulin (lower).

产品详情