产品基本信息

• 产品货号 RM5290
• 别名 Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3; NR4A1; GFRP1; HMR; NAK1;
• 产品名称 NUR77 (11I19) Rabbit Monoclonal Antibody
• 类别 抗原抗体
• 基因名称 NR4A1
• 蛋白名称 GFRP1, HMR, NAK1
• Clonality Monoclonal
• 推荐应用 WB
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
• Human Gene ID 3164
• 免疫原 A synthetic peptide of human NUR77
• 稀释度 WB 1:1000-1:5000
• 参考分子量 65kDa
• 预测分子量 65kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 IgG
• 注意事项 NUR77 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
• 组织表达 Fetal muscle and adult liver, brain and thyroid.
• 细胞定位 Nucleus. Cytoplasm. Mitochondrion. Note=Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340) Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950)
• 功能 Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).

图片

Western blot detection of NUR77 in Rat Brain lysates using NUR77 antibody(1:500 diluted).

产品详情