产品基本信息

• 产品货号 RM5278
• 别名 ABC29; Abcc1; GSX; Leukotriene C(4) transporter; LTC4 transporter; MRP1;
• 产品名称 MRP1 (7D13) Rabbit Monoclonal Antibody
• 类别 抗原抗体
• 基因名称 ABCC1
• 蛋白名称 MRP, MRP1
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-ICC,IF-P
• 反应种属 Human
• 存储缓冲液 Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
• Human Gene ID 4363
• 免疫原 A synthetic peptide of human MRP1
• 稀释度 WB 1:1000, IHC-P/IF-P 1:500, IF-ICC 1:20-1:100
• 参考分子量 170-220kDa
• 预测分子量 172kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 IgG
• 注意事项 MRP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
• 组织表达 Lung, testis and peripheral blood mononuclear cells
• 细胞定位 Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:16230346}
• 功能 Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17- beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).

图片

Western blot analysis of MRP1 expression in A431 cell lysate.

产品详情