产品基本信息
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产品货号
RM4176
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别名
c-Myc; Class E basic helix-loop-helix protein 39; MRTL; MYC; Myc proto-oncogene protein; v-myc;
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产品名称
c-Myc (9U18) Rabbit Monoclonal Antibody
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类别
抗原抗体
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基因名称
MYC
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蛋白名称
BHLHE39
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Clonality
Monoclonal
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推荐应用
WB,IHC-P,IF-ICC,FCM,IP,IF-P
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反应种属
Human,Mouse,Rat
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存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
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Human Gene ID
4609
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Human Swissprot No.
P01106
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免疫原
A synthetic peptide of human c-Myc
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稀释度
WB 1:2000, IHC-P/IF-P 1:200, IF-ICC 1:100, FCM 1:100, IP 1:50
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参考分子量
57-65kDa
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预测分子量
49kDa
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运输及保存条件
-20°C/1 year
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宿主
Rabbit
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同种型
IgG
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注意事项
c-Myc Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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细胞定位
Nucleus, nucleoplasm. Nucleus, nucleolus
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功能
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).
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期货
现货
图片
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Western blot detection of c-Myc in HeLa cell lysates using c-Myc antibody(1:1000 diluted). |
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Western blot detection of c-Myc in K562,C6,3T3,Hela cell lysates using c-Myc antibody(1:1000 diluted). |
产品详情
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Myc a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors.. Seems to activate the transcription of growth-related genes.