产品基本信息

• 产品货号 BDAF0008
• 别名 Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 Ligand 1; Programmed Death Ligand 1; B7 Homolog 1; B7-H1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
• 产品名称 Recombinant Human PD-L1 (C-Fc)
• 类别 诊断原料
• 推荐应用 Dependent by end user
• 存储缓冲液 Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
• Human Swissprot No. Q9NZQ7
• 参考分子量 70-80kDa, reducing conditions
• 预测分子量 123kDa
• 运输及保存条件 Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
• 表达系统 human cells
• 内毒素 Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
• 宿主 human cells
• 背景介绍 CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

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