产品基本信息

• 产品货号 BDAB0060
• 别名 5F7 Protein, Human; Basigin Protein, Human; CD147 Protein, Human; EMMPRIN Protein, Human; M6 Protein, Human; OK Protein, Human; TCSF Protein, Human
• 产品名称 Recombinant Human CD147 protein
• 类别 病原微生物抗原抗体假病毒
• 推荐应用 Immunogen
• 存储缓冲液 Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5
• 特异性 Homo sapiens (Human)
• 参考分子量 22.59 kDa
• 运输及保存条件 Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 2 to 8 °C for one week .Store at -20 to -80 °C for twelve months from the date of receipt.
• 宿主 E.coli
• type1 His tag
• 注意事项 CD147
• limitation For?research?use?only?.
• 背景介绍 CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.
• 纯化 >90% as determined by SDS-PAGE

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