产品基本信息

• 产品货号 BD-PB2897
• 别名 Heat shock protein HSP 90-alpha 1, hsp90a1, hsp90, hsp90a, hsp90aa1
• 产品名称 hsp90a.1 Rabbit Polyclonal Antibody (Center)
• 类别 抗原抗体
• 推荐应用 WB, IHC-P
• 反应种属 Zebrafish
• Human Swissprot No. Q90474
• 特异性 This hsp90a.1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 229-263 amino acids from the Central region of human (DANRE) hsp90a.1.
• 稀释度 WB 1:2000
• 预测分子量 83kDa
• 同种型 Rabbit Ig
• 背景介绍 Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Plays a key role in slow and fast muscle development in the embryo. Plays a role in myosin expression and assembly.
• 组织表达 Strongly expressed in the early embryos within the somitic slow muscle progenitors, the adaxial cells that lie on either side of the notochord but not the notochord. Also expressed during the early differentiation of fast fibers. Detected in developing cardiac muscles and pectoral fin primordia. Not detected in mature muscle fibers.
• 细胞定位 Melanosome {ECO:0000250|UniProtKB:P07900}. Cytoplasm, myofibril, sarcomere, Z line Cytoplasm, myofibril, sarcomere, A band Cytoplasm, perinuclear region Note=Expressed at the Z line and in the perinuclear region of myofibrils. Shuttles between the Z line and A band in response to stress conditions and fibril damage

图片

	Anti-hsp90a. 1 Antibody (Center) at 1:2000 dilution + ZF4 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 83 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
	All lanes : Anti-hsp90a. 1 Antibody (Center) at 1:2000 dilution Lane 1: Zebrafish muscle lysate Lane 2: Zebrafish lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 83 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

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