产品基本信息
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产品货号
BD-PA0009
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别名
MEK2; MKK2; MAPKK2
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产品名称
MAP2K2 Mouse Monoclonal Antibody
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类别
抗原抗体
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基因名称
MAP2K2
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Clonality
Monoclonal
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推荐应用
WB,ICC,FCM,Elisa
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反应种属
Human,Mouse,Rat
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存储缓冲液
Ascitic fluid containing 0.03% New type preservative N.
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Human Gene ID
5605
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免疫原
Purified recombinant fragment of human MAP2K2 expressed in E. Coli.
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稀释度
WB 1:500-1:2000, ICC 1:200-1:1000, FCM 1:200-1:400, ELISA 1:10000
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参考分子量
44kDa
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运输及保存条件
4℃; -20℃ for long term storage. Avoid freeze/thaw cycles.
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宿主
Mouse
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同种型
IgG1
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克隆号
7F5
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期货
3个工作日
图片
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Western blot analysis using MAP2K2 mouse mAb against PC-12 (1), Jurkat (2), Hela (3) and NIH/3T3 (4) cell lysate. |
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Immunofluorescence analysis of Hela cells using anti-MAP2K2 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. |
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Flow cytometric analysis of Hela cells using anti-MAP2K2 mAb (green) and negative control (purple). |
产品详情
MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
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