产品基本信息
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产品货号
BD-PA0001
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别名
HHD; BCPM; PMR1; SPCA1
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产品名称
ATP2C1 Mouse Monoclonal Antibody
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类别
抗原抗体
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基因名称
ATP2C1
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Clonality
Monoclonal
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推荐应用
WB,IHC-P,Elisa
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反应种属
Human,Monkey
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存储缓冲液
Ascitic fluid containing 0.03% New type preservative N.
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Human Gene ID
27032
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免疫原
Purified recombinant fragment of ATP2C1 expressed in E. Coli.
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稀释度
WB 1:500-1:2000, IHC-P 1:200-1:1000, ELISA 1:10000
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参考分子量
100kDa
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运输及保存条件
4℃; -20℃ for long term storage. Avoid freeze/thaw cycles.
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宿主
Mouse
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同种型
IgG1
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克隆号
4G12
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期货
3个工作日
图片
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Western blot analysis using ATP2C1 mouse mAb against A431 (1), Hela (2) and HEK293 (3) cell lysate. |
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Immunohistochemical analysis of paraffin-embedded human ovarian cancer (left) and breast cancer (right) tissues using ATP2C1 mouse mAb with DAB staining. |
产品详情
ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
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