产品基本信息
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产品货号
BD-PA0011
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别名
THPOK; ZFP67; ZBTB15; c-Krox; hcKrox; ZNF857B; DKFZp686G01254; ZBTB7B
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产品名称
ZBTB7B Mouse Monoclonal Antibody
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类别
抗体产品
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基因名称
ZBTB7B
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Clonality
Monoclonal
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推荐应用
WB,IHC-P,ICC,Elisa
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反应种属
Human
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存储缓冲液
Ascitic fluid containing 0.03% New type preservative N.
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Human Gene ID
51043
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免疫原
Purified recombinant fragment of human ZBTB7B expressed in E. Coli.
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稀释度
WB 1:500-1:2000, IHC-P 1:200-1:1000, ICC 1:200-1:1000, ELISA 1:10000
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参考分子量
58kDa
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运输及保存条件
Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
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宿主
Mouse
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同种型
IgG1
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克隆号
7C12
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纯度
crude ascites
图片
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Western blot analysis using ZBTB7B mAb against HEK293 (1,2) cell lysate. |
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Immunofluorescence analysis of Hela cells using ZBTB7B mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin |
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Immunohistochemical analysis of paraffin-embedded human Breast tissues using anti-ZBTB7B mouse mAb |
产品详情
ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.