产品基本信息
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产品货号
BD-PA0224
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别名
p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B
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产品名称
NFKB1 Mouse Monoclonal Antibody
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类别
抗原抗体
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基因名称
NFKB1
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Clonality
Monoclonal
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推荐应用
WB,IHC-P,FCM,Elisa
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反应种属
Human
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存储缓冲液
Ascitic fluid containing 0.03% New type preservative N.
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Human Gene ID
4790
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免疫原
Purified recombinant fragment of human NFKB1 expressed in E. Coli.
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稀释度
WB 1:500-1:2000, IHC-P 1:200-1:1000, FCM 1:200-1:400, ELISA 1:10000
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参考分子量
50kDa/105kDa
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运输及保存条件
4℃; -20℃ for long term storage. Avoid freeze/thaw cycles.
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宿主
Mouse
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同种型
IgG2a
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克隆号
5D10
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期货
3个工作日
图片
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Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng); |
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Western blot analysis using NFKB1 mouse mAb against K562 (1), Jurkat (2), A431 (3), Hela (4), THP-1 (5) and MCF-7 (6) cell lysate. |
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Flow cytometric analysis of MCF-7 cells using NFKB1 mouse mAb (green) and negative control (purple). |
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Immunohistochemical analysis of paraffin-embedded human prostate tissues (left) and bladder cancer tissues (right) using NFKB1 mouse mAb with DAB staining. |
产品详情
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
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