产品基本信息

• 产品货号 BD-PT6117
• 别名 Microtubule-associated protein 4 (MAP-4)
• 产品名称 MAP4 Rabbit Polyclonal Antibody
• 类别 抗体产品
• 基因名称 MAP4
• 蛋白名称 Microtubule-associated protein 4 (MAP-4)
• Clonality Polyclonal
• 推荐应用 WB,ELISA
• 反应种属 Human,Mouse,Rat
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 4134
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4134
• Human Swissprot No. P27816
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P27816/entry
• Mouse Gene ID 17758
• Mouse Swissprot No. P27546
• Mouse Swissprot Link http://www.uniprot.org/uniprot/P27546
• Rat Gene ID 367171
• Rat Swissprot No. Q5M7W5
• Rat Swissprot Link http://www.uniprot.org/uniprot/O54941Q5M7W5
• 免疫原 Synthesized peptide derived from human MAP4 Polyclonal
• 特异性 This antibody detects endogenous levels of MAP4.
• 稀释度 WB 1:500-2000, ELISA 1:10000-20000
• 预测分子量 121kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
• 组织表达 Bone marrow,Brain,Cerebellum,Colon carcinoma,Epithelium,Eye,Heart,Liver,Lym
• 细胞定位 Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center . Recruitment to microtubule is inhibited by microtubules polyglutamylation. .
• 功能 alternative products:Additional isoforms seem to exist,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Non-neuronal microtubule-associated protein. Promotes microtubule assembly.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

Western blot analysis of various lysate, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000

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