产品基本信息

• 产品货号 BD-PT1282
• 别名 DAB1; Disabled homolog 1
• 产品名称 Dab1 Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 DAB1
• 蛋白名称 Disabled homolog 1
• Clonality Polyclonal
• 推荐应用 WB,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Mouse,Rat
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 1600
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1600
• Human Swissprot Link http://www.uniprot.org/uniprotkb/O75553/entry
• Mouse Gene ID 13131
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13131
• Mouse Swissprot No. P97318
• Mouse Swissprot Link http://www.uniprot.org/uniprot/P97318
• Rat Gene ID 266729
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=266729
• Rat Swissprot No. Q8CJH2
• Rat Swissprot Link http://www.uniprot.org/uniprot/Q8CJH2
• 免疫原 The antiserum was produced against synthesized peptide derived from human Dab1. AA range:199-248
• 特异性 Dab1 Polyclonal Antibody detects endogenous levels of Dab1 protein.
• 稀释度 WB 1:500-1:2000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:20000.Not yet tested in other applications.
• 预测分子量 80kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008],
• 组织表达 Mainly expressed in brain.
• 细胞定位 nucleolus,microtubule organizing center,cytosol,brush border,postsynaptic density,membrane,neuron projection,neuronal cell body,intracellular membrane-bounded organelle,apical part of cell,perinuclear region of cytoplasm,
• 功能 domain:The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.,function:Adapter molecule functioning in neural development. May regulate SIAH1 activity.,PTM:Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling.,similarity:Contains 1 PID domain.,subunit:Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Immunofluorescence analysis of MCF7 cells, using Dab1 Antibody. The picture on the right is blocked with the synthesized peptide.
	Western blot analysis of lysates from HepG2 and 293 cells, using Dab1 Antibody. The lane on the right is blocked with the synthesized peptide.
	Western Blot analysis of various cells using Dab1 Polyclonal Antibody
	Western Blot analysis of 293 cells using Dab1 Polyclonal Antibody

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