产品基本信息

• 产品货号 BD-PT0938
• 别名 CCR7; CMKBR7; EBI1; EVI1; C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD antigen CD19
• 产品名称 CKR-7 Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 CCR7
• 蛋白名称 C-C chemokine receptor type 7
• Clonality Polyclonal
• 推荐应用 WB,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Monkey
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 1236
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1236
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P32248/entry
• Mouse Swissprot No. P47774
• Mouse Swissprot Link http://www.uniprot.org/uniprot/P47774
• 免疫原 The antiserum was produced against synthesized peptide derived from human CCR7. AA range:170-219
• 特异性 CKR-7 Polyclonal Antibody detects endogenous levels of CKR-7 protein.
• 稀释度 WB 1:500-1:2000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:40000.Not yet tested in other applications.
• 预测分子量 43kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014],
• 组织表达 Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
• 细胞定位 Cell membrane; Multi-pass membrane protein.
• 信号通路 Cytokine-cytokine receptor interaction;Chemokine;
• 功能 function:Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.,induction:By EBV.,online information:CC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Immunofluorescence analysis of A549 cells, using CCR7 Antibody. The picture on the right is blocked with the synthesized peptide.
	Western blot analysis of lysates from COS7 cells, using CCR7 Antibody. The lane on the right is blocked with the synthesized peptide.
	Western blot analysis of the lysates from HeLa cells using CCR7 antibody.
	Western Blot analysis of COS-7 cells using CKR-7 Polyclonal Antibody

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