产品基本信息

• 产品货号 RM8256
• 别名 SP1;TSFP1;Transcription factor Sp1
• 产品名称 SP1 (4Z14) Rabbit Monoclonal Antibody
• 类别 抗原抗体
• 基因名称 SP1
• 蛋白名称 Transcription factor Sp1
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 6667
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6667
• Human Swissprot No. P08047
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P08047/entry
• Mouse Gene ID 20683
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20683
• Mouse Swissprot No. O89090
• Mouse Swissprot Link http://www.uniprot.org/uniprot/O89090
• Rat Gene ID 24790
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24790
• Rat Swissprot No. Q01714
• Rat Swissprot Link http://www.uniprot.org/uniprot/Q01714
• 稀释度 IHC-P 1:200-1000,WB 1:1000-5000,IF-P/IF-F/IF-ICC 1:200-1000,ELISA 1:5000-20000,IP 1:50-200
• 参考分子量 100kDa
• 预测分子量 100kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014],
• 信号通路 TGF-beta;Huntington's disease;
• 功能 function:Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter.,PTM:O-glycosylated; contains N-acetylglucosamine side chains.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with ATF7IP, ATF7IP2, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein and HIV-1 Vpr. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the two proteins in DNA binding.,
• 期货 现货
• 纯化 Protein A

图片

Western blot analysis of lysates from Caco-2 cells, using SP1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.

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