产品基本信息

• 产品货号 BD-PT0753
• 别名 KLRK1; D12S2489E; NKG2D; NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD antigen CD314
• 产品名称 CD314 Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 KLRK1
• 蛋白名称 NKG2-D type II integral membrane protein
• Clonality Polyclonal
• 推荐应用 WB,ELISA
• 反应种属 Human,Rat,Mouse
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 22914
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22914
• Human Swissprot No. P26718
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P26718/entry
• Mouse Swissprot No. O54709
• Mouse Swissprot Link http://www.uniprot.org/uniprot/O54709
• 免疫原 The antiserum was produced against synthesized peptide derived from human KLRK1. AA range:111-160
• 特异性 CD314 Polyclonal Antibody detects endogenous levels of CD314 protein.
• 稀释度 WB 1:500-1:2000, ELISA 1:10000.Not yet tested in other applications.
• 预测分子量 25kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of
• 组织表达 Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
• 细胞定位 Cell membrane ; Single-pass type II membrane protein . Colocalized with HCST on the cell surface.
• 信号通路 Natural killer cell mediated cytotoxicity;
• 功能 alternative products:A number of isoforms are produced,function:Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.,miscellaneous:Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs.,online information:NKG-2D,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.,tissue specificity:Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs).,
• 期货 现货
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Western blot analysis of KLRK1 Antibody. The lane on the right is blocked with the KLRK1 peptide.
	Western Blot analysis of 3T3 cells using CD314 Polyclonal Antibody

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