产品基本信息

• 产品货号 BD-PT0732
• 别名 SIRPB1; Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD antigen CD172b
• 产品名称 CD172b Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 SIRPB1
• 蛋白名称 Signal-regulatory protein beta-1
• Clonality Polyclonal
• 推荐应用 WB,ELISA
• 反应种属 Human,Rat,Mouse
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 10326
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10326
• Human Swissprot No. O00241
• Human Swissprot Link http://www.uniprot.org/uniprotkb/O00241/entry
• 免疫原 The antiserum was produced against synthesized peptide derived from human SIRPB1. AA range:231-280
• 特异性 CD172b Polyclonal Antibody detects endogenous levels of CD172b protein.
• 稀释度 WB 1:500-1:2000, ELISA 1:5000.Not yet tested in other applications.
• 预测分子量 48kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],
• 组织表达 Detected in monocytes and dendritic cells.
• 细胞定位 Cell membrane ; Single-pass type I membrane protein .
• 功能 function:Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.,function:Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.,PTM:N-glycosylated.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C1-type (immunoglobulin-like) domains.,subunit:Interacts with TYROBP. This interaction results in the recruitment of SYK.,tissue specificity:Detected in monocytes and dendritic cells.,
• 期货 现货
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Western blot analysis of lysates from HeLa, COLO, and HUVEC cells, using SIRPB1 Antibody. The lane on the right is blocked with the synthesized peptide.
	Western Blot analysis of various cells using CD172b Polyclonal Antibody

产品详情