产品基本信息

• 产品货号 BD-PT0644
• 别名 CSNK2B; CK2N; G5A; Casein kinase II subunit beta; CK II beta; Phosvitin; Protein G5a
• 产品名称 Casein Kinase IIβ Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 CSNK2B
• 蛋白名称 Casein kinase II subunit beta
• Clonality Polyclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Mouse,Rat
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 1460
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1460
• Human Swissprot No. P67870
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P67870/entry
• Mouse Gene ID 13001
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13001
• Mouse Swissprot No. P67871
• Mouse Swissprot Link http://www.uniprot.org/uniprot/P67871
• Rat Gene ID 81650
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81650
• Rat Swissprot No. P67874
• Rat Swissprot Link http://www.uniprot.org/uniprot/P67874
• 免疫原 The antiserum was produced against synthesized peptide derived from human CKII-beta. AA range:166-215
• 特异性 Casein Kinase IIβ Polyclonal Antibody detects endogenous levels of Casein Kinase IIβ protein.
• 稀释度 WB 1:500-1:2000, IHC-P 1:100-1:300, ELISA 1:5000, IF-P/IF-F/IF-ICC 1:50-200
• 预测分子量 25kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013],
• 组织表达 Brain,Epithelium,
• 细胞定位 nucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,protein kinase CK2 complex,PcG protein complex,extracellular exosome,
• 信号通路 WNT;WNT-T CELLAdherens_Junction;Adherens_Junction;
• 功能 function:Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.,PTM:N-glycosylated.,PTM:Phosphorylated by alpha subunit.,similarity:Belongs to the casein kinase 2 subunit beta family.,similarity:Contains 1 UPAR/Ly6 domain.,subunit:Forms oligomer.,subunit:Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.,
• 期货 现货
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CKII-beta Antibody. The picture on the right is blocked with the synthesized peptide.
	Western blot analysis of lysates from HUVEC cells, using CKII-beta Antibody. The lane on the right is blocked with the synthesized peptide.
	Western Blot analysis of various cells using Casein Kinase IIβ Polyclonal Antibody

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