产品基本信息

• 产品货号 BD-PT0625
• 别名 CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CaMK-II subunit gamma; CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit bet
• 产品名称 CaMKIIβ/γ Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 CAMK2B/CAMK2G
• 蛋白名称 Calcium/calmodulin-dependent protein kinase type II subunit beta/gamma
• Clonality Polyclonal
• 推荐应用 WB,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Mouse,Rat
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 818/816
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=818
• Human Swissprot Link http://www.uniprot.org/uniprotkb/Q13555/entry
• Mouse Gene ID 12325/12323
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12325
• Rat Gene ID 171140/24245
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171140
• Rat Swissprot No. P11730/P08413
• Rat Swissprot Link http://www.uniprot.org/uniprot/P11730
• 免疫原 The antiserum was produced against synthesized peptide derived from human CaMK2 beta/gamma. AA range:509-558
• 特异性 CaMKIIβ/γ Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ protein.
• 稀释度 WB 1:500-1:2000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:20000.Not yet tested in other applications.
• 预测分子量 62kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011],
• 组织表达 Expressed in skeletal muscle.
• 细胞定位 Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .
• 信号通路 ErbB_HER;Calcium;Oocyte meiosis;WNT;WNT-T CELLLong-term potentiation;Neurotrophin;Olfactory transduction;GnRH;Melanogenesis;Glioma;
• 功能 catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Western blot analysis of lysates from COLO205 and Jurkat cells, using CaMK2 beta/gamma Antibody. The lane on the right is blocked with the synthesized peptide.
	Western Blot analysis of various cells using CaMKIIβ/γ Polyclonal Antibody

产品详情