产品基本信息

• 产品货号 BD-PT0514
• 别名 BDKRB1; BRADYB1; B1 bradykinin receptor; B1R; BK-1 receptor
• 产品名称 Bradykinin B1 R Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 BDKRB1
• 蛋白名称 B1 bradykinin receptor
• Clonality Polyclonal
• 推荐应用 WB,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Rat,Mouse
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 623
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=623
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P46663/entry
• Mouse Swissprot No. Q61125
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q61125
• 免疫原 The antiserum was produced against synthesized peptide derived from human BDKRB1. AA range:201-250
• 特异性 Bradykinin B1 R Polyclonal Antibody detects endogenous levels of Bradykinin B1 R protein.
• 稀释度 WB 1:500-1:2000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000.Not yet tested in other applications.
• 预测分子量 40kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
• 组织表达 Lung,Skin,
• 细胞定位 Cell membrane; Multi-pass membrane protein.
• 信号通路 Calcium;Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Regulates Actin and Cytoskeleton;
• 功能 function:This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.,online information:Bradykinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Immunofluorescence analysis of LOVO cells, using BDKRB1 Antibody. The picture on the right is blocked with the synthesized peptide.
	Western blot analysis of lysates from K562 cells, using BDKRB1 Antibody. The lane on the right is blocked with the synthesized peptide.

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