产品基本信息

• 产品货号 BD-PT0423
• 别名 AVPR2; ADHR; DIR; DIR3; V2R; Vasopressin V2 receptor; V2R; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
• 产品名称 AVP Receptor V2 Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 AVPR2
• 蛋白名称 Vasopressin V2 receptor
• Clonality Polyclonal
• 推荐应用 WB,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Rat,Mouse
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 554
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=554
• Human Swissprot No. P30518
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P30518/entry
• Mouse Swissprot No. O88721
• Mouse Swissprot Link http://www.uniprot.org/uniprot/O88721
• 免疫原 The antiserum was produced against synthesized peptide derived from human AVPR2. AA range:72-121
• 特异性 AVP Receptor V2 Polyclonal Antibody detects endogenous levels of AVP Receptor V2 protein.
• 稀释度 WB 1:500-1:2000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:10000.Not yet tested in other applications.
• 预测分子量 38kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus
• 组织表达 Kidney.
• 细胞定位 Cell membrane ; Multi-pass membrane protein .
• 信号通路 Neuroactive ligand-receptor interaction;
• 功能 disease:Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI) [MIM:304800]; also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia.,disease:Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.,function:Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,online information:AVPR2 pages,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Kidney.,
• 期货 现货
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Immunofluorescence analysis of MCF7 cells, using AVPR2 Antibody. The picture on the right is blocked with the synthesized peptide.
	Western blot analysis of lysates from RAW264.7 cells, using AVPR2 Antibody. The lane on the right is blocked with the synthesized peptide.
	Western blot analysis of the lysates from Jurkat cells using AVPR2 antibody.

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