产品基本信息

• 产品货号 BD-PT0287
• 别名 AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule
• 产品名称 AQP1 Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 AQP1
• 蛋白名称 Aquaporin-1
• Clonality Polyclonal
• 推荐应用 WB,ELISA
• 反应种属 Human,Mouse,Rat
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 358
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=358
• Human Swissprot No. P29972
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P29972/entry
• Mouse Gene ID 11826
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11826
• Mouse Swissprot No. Q02013
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q02013
• Rat Gene ID 25240
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25240
• Rat Swissprot No. P29975
• Rat Swissprot Link http://www.uniprot.org/uniprot/P29975
• 免疫原 The antiserum was produced against synthesized peptide derived from human AQP1. AA range:101-150
• 特异性 AQP1 Polyclonal Antibody detects endogenous levels of AQP1 protein.
• 稀释度 WB 1:500-1:2000, ELISA 1:40000.Not yet tested in other applications.
• 预测分子量 29kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. [provided by RefSeq, Aug 2016],
• 组织表达 Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.
• 细胞定位 Cell membrane ; Multi-pass membrane protein .
• 功能 domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.,miscellaneous:Pharmacologically inhibited by submillimolar concentrations of mercury.,online information:Blood group antigen gene mutation database,online information:Liquid states - Issue 36 of July 2003,polymorphism:AQP1 is responsible for the Colton blood group system. Approximately 92% of Caucasians are Co(A+B-) (Ala-46), approximately 8% are Co(A+B+), and only 0.2% are Co(A-B+) (Val-46). Co(A-B-) which is very rare, is due to a complete absence of AQP1.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,subunit:Homotetramer.,tissue specificity:Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.,
• 期货 现货
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

Western blot analysis of lysates from rat brain cells, using AQP1 Antibody. The lane on the right is blocked with the synthesized peptide.

产品详情