产品基本信息

• 产品货号 BD-PT0094
• 别名 SLC27A4; ACSVL4; FATP4; Long-chain fatty acid transport protein 4; FATP-4; Fatty acid transport protein 4; Solute carrier family 27 member 4
• 产品名称 ACSVL4 Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 SLC27A4
• 蛋白名称 Long-chain fatty acid transport protein 4
• Clonality Polyclonal
• 推荐应用 IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Rat,Mouse
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 10999
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10999
• Human Swissprot Link http://www.uniprot.org/uniprotkb/Q6P1M0/entry
• Mouse Swissprot No. Q91VE0
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q91VE0
• 免疫原 The antiserum was produced against synthesized peptide derived from human SLC27A4. AA range:61-110
• 特异性 ACSVL4 Polyclonal Antibody detects endogenous levels of ACSVL4 protein.
• 稀释度 IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:20000.Not yet tested in other applications.
• 参考分子量 72kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010],
• 组织表达 Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue (PubMed:24269233, PubMed:9878842). Expressed in brain gray matter (PubMed:21395585).
• 细胞定位 Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• 信号通路 PPAR;
• 功能 function:Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.,miscellaneous:SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with aquired obesity.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,tissue specificity:Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.,
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

Immunofluorescence analysis of A549 cells, using SLC27A4 Antibody. The picture on the right is blocked with the synthesized peptide.

产品详情