产品基本信息

• 产品货号 BD-PT0046
• 别名 ABCB7; ABC7; ATP-binding cassette sub-family B member 7; mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein
• 产品名称 ABCB7 Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 ABCB7
• 蛋白名称 ATP-binding cassette sub-family B member 7 mitochondrial
• Clonality Polyclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human,Rat,Mouse
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 22
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22
• Human Swissprot No. O75027
• Human Swissprot Link http://www.uniprot.org/uniprotkb/O75027/entry
• Mouse Swissprot No. Q61102
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q61102
• 免疫原 The antiserum was produced against synthesized peptide derived from human ABCB7. AA range:691-740
• 特异性 ABCB7 Polyclonal Antibody detects endogenous levels of ABCB7 protein.
• 稀释度 WB 1:500-1:2000, IHC-P 1:100-1:300, ELISA 1:40000, IF-P/IF-F/IF-ICC 1:50-200
• 预测分子量 Human:83kDa,Mouse/Rat 100kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms hav
• 组织表达 Human esophagus tumor,Muscle,Placenta,Umbilical cord blood,
• 细胞定位 Mitochondrion inner membrane ; Multi-pass membrane protein .
• 信号通路 ABC transporters;
• 功能 disease:Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT) [MIM:301310]. ASAT is a recessive disorder characterized by an infantile to early childhood onset of nonprogressive cerebellar ataxia and mild anemia with hypochromia and microcytosis.,function:Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.,similarity:Belongs to the ABC transporter family. Heavy Metal importer (TC 3.A.1.210) subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 ABC transporter domain.,subunit:Homodimer or heterodimer .,
• 期货 现货
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Immunohistochemistry analysis of paraffin-embedded human thymus gland, using ABCB7 Antibody. The picture on the right is blocked with the synthesized peptide.
	Western blot analysis of the lysates from HUVECcells using ABCB7 antibody.
	Western Blot analysis of various cells using ABCB7 Polyclonal Antibody diluted at 1：1000
	Western Blot analysis of various cells using antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000

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