产品基本信息

• 产品货号 BD-PC0045
• 别名 CTSL2; CATL2; CTSU; CTSV; Cathepsin L2; Cathepsin U; Cathepsin V
• 产品名称 Cathepsin L2 (Cleaved L114) Rabbit Polyclonal Antibody
• 类别 抗原抗体
• 基因名称 CTSL2
• 蛋白名称 Cathepsin L2
• Clonality Polyclonal
• 推荐应用 WB,ELISA
• 反应种属 Human,Monkey
• 浓度 1 mg/ml
• 存储缓冲液 Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
• Human Gene ID 1515
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1515
• Human Swissprot No. O60911
• Human Swissprot Link http://www.uniprot.org/uniprotkb/O60911/entry
• 免疫原 The antiserum was produced against synthesized peptide derived from human CATL2. AA range:95-144
• 特异性 Cleaved-Cathepsin L2 (L114) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin L2 protein resulting from cleavage adjacent to L114.
• 稀释度 WB 1:500-1:2000, ELISA 1:20000.Not yet tested in other applications.
• 预测分子量 37kDa
• 运输及保存条件 -20°C/1 year
• 宿主 Rabbit
• 同种型 Rabbit,IgG
• 背景介绍 The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011],
• 组织表达 Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
• 细胞定位 Lysosome .
• 信号通路 Lysosome;
• 功能 catalytic activity:The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).,function:Cysteine protease. May have an important role in corneal physiology.,similarity:Belongs to the peptidase C1 family.,tissue specificity:Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin.,
• 期货 现货
• 纯化 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

图片

	Western blot analysis of lysates from 293 and COS cells, treated with etoposide 25uM 1h, using CATL2 （Cleaved-Leu114） Antibody. The lane on the right is blocked with the synthesized peptide.
	Western Blot analysis of various cells using Cleaved-Cathepsin L2 （L114） Polyclonal Antibody

产品详情