产品基本信息

• 产品货号 B8008
• 别名 TUBB3;TUBB4;Tubulin beta-3 chain;Tubulin beta-4 chain;Tubulin beta-III
• 产品名称 Tubulin beta-3 (12Z6) Rabbit Monoclonal Antibody
• 类别 抗原抗体
• 基因名称 TUBB3
• 蛋白名称 Tubulin beta-3 chain
• 推荐应用 WB,ELISA
• 反应种属 Human,Mouse (predicted: Rat)
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 10381
• Human Swissprot No. Q13509
• Mouse Gene ID 22152
• Mouse Swissprot No. Q9ERD7
• Rat Gene ID 246118
• Rat Swissprot No. Q4QRB4
• 免疫原 Synthesized peptide derived from human protein. AA range:400-450
• 特异性 endogenous
• 稀释度 WB 1:500-2000, ELISA 1:20000
• 参考分子量 50kDa
• 预测分子量 50kDa
• 运输及保存条件 -15°C to -25°C/1 year(Do not lower than -25°C)
• 宿主 Monoclonal Rabbit IgG1, Kappa
• 背景介绍 tubulin beta 3 class III(TUBB3) Homo sapiens This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010],
• 细胞定位 Cytoplasm, cytoskeleton . Cell projection, growth cone . Cell projection, lamellipodium . Cell projection, filopodium .
• 表达 Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues.
• 功能 domain:The highly acidic C-terminal region may bind cations such as calcium.,function:Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,polymorphism:Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2 (SHEP2) [MIM:266300]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator.
• 纯化 Protein A

图片

Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with β-actin Rabbit Monoclonal Antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1:A431 Lane 2:HEK293 Predicted band size: 50kDa Observed band size: 50kDa

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