产品基本信息

• 产品货号 BD-PM6069
• 别名 Gastric mucin 6;Gastric Mucin;Gastric mucin-6;MUC 6;MUC-6;Muc6;MUC6 Fragment;MUC6 mucin;MUC6 mucin Fragment;MUC6_HUMAN;Mucin 6;Mucin 6 gastric;Mucin 6 oligomeric mucus/gel forming;Mucin glycoprotein Fragment;Mucin-6;Secretory mucin MUC6 Fragment
• 产品名称 Gastrin (6V7) Mouse Monoclonal Antibody
• 类别 抗原抗体
• 基因名称 GAST GAS
• 蛋白名称 Gastric mucin 6;Gastric Mucin;Gastric mucin-6;MUC 6;MUC-6;Muc6;MUC6 Fragment;MUC6 mucin;MUC6 mucin Fragment;MUC6_HUMAN;Mucin 6;Mucin 6 gastric;Mucin 6 oligomeric mucus/gel forming;Mucin glycoprotein Fragment;Mucin-6;Secretory mucin MUC6 Fragment
• 推荐应用 IHC-P,IF-P,IF-F,IF-ICC,ELISA
• 反应种属 Human
• 制备方法 The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
• 存储缓冲液 PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
• Human Swissprot Link https://www.uniprot.org/uniprotkb/P01350/entry
• Mouse Swissprot No. P48757
• Rat Swissprot No. P04563
• 特异性 The antibody can specifically recognize human Gastrin protein.. The antibody was also Predict react with Mouse;Rat
• 稀释度 IHC-P 1:200-400. IF-P/IF-F/IF-ICC 1:50-200. ELISA 1:500-5000
• 预测分子量 11kD
• 运输及保存条件 -15°C to -25°C/1 year(Do not lower than -25°C)
• 组织表达 Pyloric region of the stomach
• 细胞定位 Cytoplasmic
• 功能 function:Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.,online information:Gastrin entry,PTM:Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.,PTM:Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.,similarity:Belongs to the gastrin/cholecystokinin family.,
• 纯化 The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

图片

Human gastric adenocarcinoma tissue was stained with Anti-Gastrin Antibody

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