产品基本信息

• 产品货号 BD-PM6058
• 别名 CARD2;CK 8;CK-8;CK8;CYK8;CYKER;Cytokeratin endo A;Cytokeratin-8;DreK8;EndoA;K2C8;K2C8_HUMAN;K8;Keratin 8;Keratin type II cytoskeletal 8;Keratin, type II cytoskeletal 8;Keratin-8;KO;Krt 2.8;KRT8;MGC118110;MGC174782;MGC53564;MGC85764;sb:cb186;Type-II keratin Kb8
• 产品名称 Cytokeratin 8 (9M4) Mouse Monoclonal Antibody
• 类别 抗原抗体
• 基因名称 KRT8 CYK8
• 蛋白名称 CARD2;CK 8;CK-8;CK8;CYK8;CYKER;Cytokeratin endo A;Cytokeratin-8;DreK8;EndoA;K2C8;K2C8_HUMAN;K8;Keratin 8;Keratin type II cytoskeletal 8;Keratin, type II cytoskeletal 8;Keratin-8;KO;Krt 2.8;KRT8;MGC118110;MGC174782;MGC53564;MGC85764;sb:cb186;Type-II keratin Kb8
• 推荐应用 IHC-P,WB,ELISA
• 反应种属 Human, Mouse (predicted: Rat)
• 制备方法 The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
• 存储缓冲液 PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
• Human Swissprot No. P05787
• Human Swissprot Link https://www.uniprot.org/uniprotkb/P05787/entry
• Mouse Swissprot No. P11679
• Rat Swissprot No. Q10758
• 特异性 The antibody can specifically recognize human CK8 protein, and shows no cross reaction with CK1, 4, 5, 6, 7, 10, 15, 16, 17, 18, 20.
• 稀释度 IHC-P 1:200-400, WB 1:200-1000
• 预测分子量 53kD
• 运输及保存条件 -15°C to -25°C/1 year(Do not lower than -25°C)
• 组织表达 Liver/ Tonsil
• 细胞定位 Cytoplasmic, Membranous
• 功能 disease:Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].,function:Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.,tissue specificity:Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.,
• 期货 现货
• 纯化 The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

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