产品基本信息

• 产品货号 BD-PM6056
• 别名 CK 7;CK-7;CK7;Cytokeratin 7;Cytokeratin-7;D15Wsu77e;K2C7;K2C7_HUMAN;K7;Keratin 7;Keratin 7, type II;Keratin type II cytoskeletal 7;Keratin, 55K type II cytoskeletal;Keratin, simple epithelial;Keratin, simple epithelial type I, K7;Keratin, type II cytoskeletal 7;Keratin-7;Krt2-7;KRT7;MGC11625;MGC129731;MGC3625;Sarcolectin;SCL;Type II mesothelial keratin K7;Type-II keratin Kb7
• 产品名称 Cytokeratin 7 (7L9) Mouse Monoclonal Antibody
• 类别 抗原抗体
• 基因名称 KRT7 SCL
• 蛋白名称 CK 7;CK-7;CK7;Cytokeratin 7;Cytokeratin-7;D15Wsu77e;K2C7;K2C7_HUMAN;K7;Keratin 7;Keratin 7, type II;Keratin type II cytoskeletal 7;Keratin, 55K type II cytoskeletal;Keratin, simple epithelial;Keratin, simple epithelial type I, K7;Keratin, type II cytoskeletal 7;Keratin-7;Krt2-7;KRT7;MGC11625;MGC129731;MGC3625;Sarcolectin;SCL;Type II mesothelial keratin K7;Type-II keratin Kb7
• 推荐应用 IHC-P,WB,ELISA
• 反应种属 Human
• 制备方法 The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
• 存储缓冲液 PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
• Human Swissprot No. P08729
• Human Swissprot Link https://www.uniprot.org/uniprotkb/P08729/entry
• Mouse Swissprot No. Q9DCV7
• Rat Swissprot No. Q6IG12
• 特异性 The antibody can specifically recognize human CK7 protein, and shows no cross reaction with CK1, 4, 5, 6, 8, 10, 14, 17, 18, 19, 20. In western blotting of Hela, A431, A549 and Hela cell lysates, the antibody can label a 51 kDa band corresponding to CK7 in A549 and Hela cell lysates.
• 稀释度 IHC-P 1:200-400, WB 500-1000
• 预测分子量 52kD
• 运输及保存条件 -15°C to -25°C/1 year(Do not lower than -25°C)
• 组织表达 Pancreas
• 细胞定位 Cytoplasmic, Membranous
• 功能 function:Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).,induction:Up-regulated by retinoic acid.,mass spectrometry: PubMed:11840567,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Arg-20 is dimethylated, probably to asymmetric dimethylarginine.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7.,tissue specificity:Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.,
• 期货 现货
• 纯化 The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

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