产品基本信息

• 产品货号 BD-PB2988
• 别名 Sterol regulatory element-binding protein 2, SREBP-2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2, srebf2 {ECO:0000250|UniProtKB:Q12772}
• 产品名称 (DANRE) srebf2 Rabbit Polyclonal Antibody (Center)
• 类别 抗原抗体
• 推荐应用 WB
• 反应种属 Zebrafish
• 特异性 This (DANRE) srebf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 441-473 amino acids from the Central region of human (DANRE) srebf2.
• 稀释度 WB 1:1000
• 预测分子量 120kDa
• 同种型 Rabbit Ig
• 背景介绍 Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity).
• 细胞定位 [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q12772}; Multi- pass membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q12772}; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q12772}; Multi-pass membrane protein. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed {ECO:0000250|UniProtKB:Q12772}

图片

Western blot analysis of lysates from Zebrafish and zebra fish muscle tissue lysate (from left to right), using (DANRE) srebf2 Antibody (Center). BD-PB2988 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

产品详情