产品基本信息

• 产品货号 BDAB0010
• 别名 RBD Protein, Spike RBD Protein,Isolate from travelers from Brazil,B.1.1.248,P.1,Gamma
• 产品名称 Recombinant SARS-CoV-2 (2019-nCoV) S Protein RBD(E484K、K417T、N501Y)，His Tag
• 类别 病原微生物抗原抗体假病毒
• 推荐应用 Immunogen
• 存储缓冲液 Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5
• 特异性 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
• 运输及保存条件 Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 2 to 8 °C for one week .Store at -20 to -80 °C for twelve months from the date of receipt.
• 宿主 Mammalian cells
• type1 C-His
• 注意事项 巴西突变株（B.1.1.248）
• limitation For research use only .Not for use in clinical diagnostic procedures.
• 背景介绍 Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
• 纯化 >90% as determined by SDS-PAGE

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