产品基本信息

• 产品货号 BDAF0003
• 别名 Programmed cell death protein 1; hPD-1; PDCD1; CD279
• 产品名称 Recombinant Human PD-1 (C-6His)
• 类别 诊断原料
• 推荐应用 Dependent by end user
• 存储缓冲液 Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
• Human Swissprot No. Q15116
• 参考分子量 30-40kDa, reducing conditions
• 预测分子量 17kDa
• 运输及保存条件 Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
• 表达系统 human cells
• 内毒素 Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
• 宿主 human cells
• 背景介绍 Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

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