产品基本信息

• 产品货号 BDAF0002
• 别名 ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase;CD38;T10
• 产品名称 Recombinant Human CD38 (C-Fc)
• 类别 诊断原料
• 推荐应用 Dependent by end user
• 存储缓冲液 Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
• Human Swissprot No. P28907
• 参考分子量 70-90kDa, reducing conditions
• 预测分子量 132kDa
• 运输及保存条件 Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
• 表达系统 human cells
• 内毒素 Less than 0.1 ng/µg (0 EU/µg) as determined by LAL test.
• 宿主 human cells
• 背景介绍 CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells.

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