产品基本信息

• 产品货号 RM8016
• 别名 MAPK3;ERK1;PRKM3;Mitogen-activated protein kinase 3;MAP kinase 3;MAPK 3;ERT2;Extracellular signal-regulated kinase 1;ERK-1;Insulin-stimulated MAP2 kinase;MAP kinase isoform p44;p44-MAPK;Microtubule-associated protein 2 kinase;p
• 产品名称 ERK1/2 (15Z6) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 MAPK1/MAPK3
• 蛋白名称 Mitogen-activated protein kinase 3
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 5595/5594
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5595
• Human Swissprot No. P28482,P27361
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P27361/entry
• Mouse Gene ID 26417/26413
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26417
• Rat Gene ID 50689/116590
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50689
• Rat Swissprot No. P21708/P63086
• Rat Swissprot Link http://www.uniprot.org/uniprot/P21708
• 稀释度 IHC-P 1:2000-1:10000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 43kDa,41kDa
• 预测分子量 43kDa,41kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008],
• 信号通路 Regulates Angiogenesis; Regulation_Microtubule; Regulation of Actin Dynamics; Stem cell pathway; T_Cell_Receptor; Insulin Receptor; Cell Growth; Toll_Like; MAPK_ERK_Growth;MAPK_G_Protein; B_Cell_Antigen; PI3K/Akt; mTOR
• 功能 catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by tyrosine phosphorylation in response to insulin and NGF.,function:Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).,PTM:Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MORG1 (By similarity). Binds to HIV-1 Nef. This interaction inhibits its kinase activity. Interacts with HSF4 and NISCH.,
• 纯化 Protein A

图片

	Western blot analysis of lysates from 3T3-L1 cells, using ERK1/2 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.
	Mouse_liver

产品详情