产品基本信息

• 产品货号 RM8014
• 别名 YAP1;YAP65;Yorkie homolog;65 kDa Yes-associated protein;YAP65
• 产品名称 YAP (5A14) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 YAP1
• 蛋白名称 Yorkie homolog
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 10413
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10413
• Human Swissprot No. P46937
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P46937/entry
• Mouse Gene ID 22601
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22601
• Mouse Swissprot No. P46938
• Mouse Swissprot Link http://www.uniprot.org/uniprot/P46938
• Rat Gene ID 363014
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363014
• Rat Swissprot No. Q2EJA0
• Rat Swissprot Link http://www.uniprot.org/uniprot/Q2EJA0
• 稀释度 IHC-P 1:100-1:500, WB 1:500-1:2000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 65-75kDa
• 预测分子量 55kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],
• 功能 PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif.,
• 纯化 Protein A

图片

Western blot analysis of lysates from MCF7 cells, using YAP Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.

产品详情