产品基本信息

• 产品货号 RM8011
• 别名 MTOR;FRAP;FRAP1;FRAP2;RAFT1;RAPT1;Serine/threonine-protein kinase mTOR;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP12-rapamycin complex-associated protein;Mammalian target of rapamycin;mTOR;Mechanistic tar
• 产品名称 mTOR (phospho Ser2448) (18J15) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 MTOR
• 蛋白名称 Serine/threonine-protein kinase mTOR
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 2475
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2475
• Human Swissprot No. P42345
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P42345/entry
• Mouse Gene ID 56717
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56717
• Mouse Swissprot No. Q9JLN9
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q9JLN9
• Rat Gene ID 56718
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56718
• Rat Swissprot No. P42346
• Rat Swissprot Link http://www.uniprot.org/uniprot/P42346
• 稀释度 IHC-P 1:500-1:2000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 250kDa
• 预测分子量 289kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008],
• 信号通路 Regulates Angiogenesis; Insulin Receptor; ErbB/HER; mTOR; B Cell Receptor; PI3K/Akt; AMPK
• 功能 function:Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 FAT domain.,similarity:Contains 1 FATC domain.,similarity:Contains 1 PI3K/PI4K domain.,similarity:Contains 7 HEAT repeats.,subunit:Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.,tissue specificity:Expressed in numerous tissues, with highest levels in testis.,
• 纯化 Protein A

图片

	Western blot analysis of lysates from Hela cells, using mTOR (p-Ser2448) Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.
	Mouse_ovary

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