产品基本信息

• 产品货号 RM8010
• 别名 STAT3;APRF;Signal transducer and activator of transcription 3;Acute-phase response factor
• 产品名称 STAT3 (18Z18) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 STAT3
• 蛋白名称 Signal transducer and activator of transcription 3
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 6774
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6774
• Human Swissprot No. P40763
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P40763/entry
• Mouse Gene ID 20848
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20848
• Mouse Swissprot No. P42227
• Mouse Swissprot Link http://www.uniprot.org/uniprot/P42227
• Rat Gene ID 25125
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25125
• Rat Swissprot No. P52631
• Rat Swissprot Link http://www.uniprot.org/uniprot/P52631
• 稀释度 IHC-P 1:100-1:500, WB 1:1000-1:5000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 88kDa
• 预测分子量 88kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
• 信号通路 Regulation_Microtubule; SAPK_JNK; Stem cell pathway; Protein_Acetylation
• 功能 disease:Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.,function:Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.,miscellaneous:Involved in the gp130-mediated signaling pathway.,online information:STAT3 entry,online information:STAT3 mutation db,PTM:Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA. Interacts with SIPAR. Interacts (via SH2 domain) with NLK (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with TMF1.,tissue specificity:Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
• 纯化 Protein A

图片

Western blot analysis of lysates from MCF7 cells, using STAT3 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.

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