产品基本信息

• 产品货号 RM8008
• 别名 TBK1;NAK;Serine/threonine-protein kinase TBK1;NF-kappa-B-activating kinase;T2K;TANK-binding kinase 1
• 产品名称 TBK1 (5M11) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 TBK1
• 蛋白名称 Serine/threonine-protein kinase TBK1
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 29110
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29110
• Human Swissprot No. Q9UHD2
• Human Swissprot Link http://www.uniprot.org/uniprotkb/Q9UHD2/entry
• Mouse Gene ID 56480
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56480
• Mouse Swissprot No. Q9WUN2
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q9WUN2
• 稀释度 IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 84kDa
• 预测分子量 84kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010],
• 信号通路 Toll_Like;RIG-I-like receptor;Cytosolic DNA-sensing pathway;
• 功能 catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between TBK1 and SIKE. Interacts with HCV NS3, a hepatitis C virus protein and with BDV P protein, a Borna disease virus protein.,tissue specificity:Ubiquitous with higher expression in testis.,
• 纯化 Protein A

图片

	Western blot analysis of lysates from Hela cells, using TBK1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.
	Rat_spleen

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