产品基本信息

• 产品货号 RM8007
• 别名 Leukosialin (Galactoglycoprotein;GALGP;Leukocyte sialoglycoprotein;Sialophorin;CD antigen CD43)
• 产品名称 CD43 (9P8) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 SPN CD43
• 蛋白名称 Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 6693
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6693
• Human Swissprot No. P16150
• Human Swissprot Link https://www.uniprot.org/uniprotkb/P16150/entry
• Mouse Gene ID 20737
• Mouse Gene Link https://www.uniprot.org/uniprot/20737
• Mouse Swissprot No. P15702
• Mouse Swissprot Link https://www.uniprot.org/uniprotkb/P15702
• Rat Swissprot No. P13838
• Rat Swissprot Link https://www.uniprot.org/uniprotkb/P13838
• 稀释度 IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 130kDa
• 预测分子量 40kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011],
• 功能 disease:CD43 expression is defective on the T-cells of males with the immunodeficiency Wiskott-Aldrich syndrome. Affected males are susceptible to opportunistic infections and do not respond to polysaccharide antigens, reflecting defects in cytotoxic and helper T-cell functions.,function:One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.,PTM:Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.,subunit:Interacts with HIPK2 via the cytoplasmic domain.,tissue specificity:Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.,
• 纯化 Protein A

图片

Western blot analysis of lysates from HL-60 cells, using CD43 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.

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