产品基本信息

• 产品货号 RM8005
• 别名 MMP7;MPSL1;PUMP1;Matrilysin;Matrin;Matrix metalloproteinase-7;MMP-7;Pump-1 protease;Uterine metalloproteinase
• 产品名称 MMP7 (10U15) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 MMP7
• 蛋白名称 Matrilysin
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 4316
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4316
• Human Swissprot No. P09237
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P09237/entry
• Mouse Swissprot No. Q10738
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q10738
• Rat Gene ID 25335
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25335
• Rat Swissprot No. P50280
• Rat Swissprot Link http://www.uniprot.org/uniprot/P50280
• 稀释度 IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 30kDa
• 预测分子量 30kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 matrix metallopeptidase 7(MMP7) Homo sapiens This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016],
• 信号通路 WNT;WNT-T CELL
• 功能 catalytic activity:Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).,cofactor:Binds 2 calcium ions per subunit.,cofactor:Binds 2 zinc ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,
• 纯化 Protein A

图片

Western blot analysis of lysates from A549 cells, using MMP7 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.

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