产品基本信息

• 产品货号 RM8004
• 别名 MME;EPN;Neprilysin;Atriopeptidase;Common acute lymphocytic leukemia antigen;CALLA;Enkephalinase;Neutral endopeptidase 24.11;NEP;Neutral endopeptidase;Skin fibroblast elastase;SFE;CD10
• 产品名称 CD10 (3E6) Rabbit Monoclonal Antibody
• 类别 抗体产品
• 基因名称 MME
• 蛋白名称 Neprilysin
• Clonality Monoclonal
• 推荐应用 WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA
• 反应种属 Human,Mouse,Rat
• 存储缓冲液 PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
• Human Gene ID 4311
• Human Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4311
• Human Swissprot No. P08473
• Human Swissprot Link http://www.uniprot.org/uniprotkb/P08473/entry
• Mouse Gene ID 17380
• Mouse Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17380
• Mouse Swissprot No. Q61391
• Mouse Swissprot Link http://www.uniprot.org/uniprot/Q61391
• Rat Gene ID 24590
• Rat Gene Link http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24590
• Rat Swissprot No. P07861
• Rat Swissprot Link http://www.uniprot.org/uniprot/P07861
• 稀释度 IHC-P 1:1000-1:4000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
• 参考分子量 100kDa
• 预测分子量 86kDa
• 运输及保存条件 -20°C/1 year(Do not lower than -25°C)
• 宿主 Rabbit
• 同种型 Monoclonal, rabbit, IgG, Kappa
• 背景介绍 This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this
• 信号通路 Renin-angiotensin system;Hematopoietic cell lineage;Alzheimer's disease;
• 功能 catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,disease:Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.,enzyme regulation:Inhibited in a dose dependent manner by opiorphin.,function:Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).,similarity:Belongs to the peptidase M13 family.,
• 纯化 Protein A

图片

Western blot analysis of lysates from A172 cells, using CD10 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.

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